Adding a certain compound to certain chemical reactions, such as: 1190319-62-0, 6-Bromo-1H-pyrrolo[3,2-b]pyridin-2(3H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C7H5BrN2O, blongs to pyridine-derivatives compound. Computed Properties of C7H5BrN2O
Example 76 Preparation of intermediate E/Z-6-bromo-3-(3-chloro-2-fluoro-benzylidene)-1,3-dihydro-pyrrolo[3,2-b]pyridin-2-one To the mixture of 6-bromo-4-aza-2-oxindole (Sinova, 0.3 g, 1.4 mmol) and 3-chloro-2-fluorobenzaldehyde (Oakwood, 0.45 g, 2.8 mmol) in methanol (20 mL) was added piperidine (Aldrich, 0.36 g, 4.2 mmol) dropwise. The reaction mixture was heated at 50 C. and stirred for 3 h. Then the mixture was cooled to room temperature and filtered. The resulting precipitate was collected and dried to give the first batch of desired product. The filtrate was concentrated, and the residue was purified by chromatography (25-50% EtOAc in hexanes) to give the second batch of product. The two batches were combined to give E/Z-6-bromo-3-(3-chloro-2-fluoro-benzylidene)-1,3-dihydro-pyrrolo[3,2-b]pyridin-2-one as a yellow solid (0.35 g, 70%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1190319-62-0, 6-Bromo-1H-pyrrolo[3,2-b]pyridin-2(3H)-one, and friends who are interested can also refer to it.
Reference:
Patent; Bartkovitz, David Joseph; Chu, Xin-Jie; Ding, Qingjie; Karnachi, Prabha Saba; Liu, Jin-Jun; So, Sung-Sau; Zhang, Jing; Zhang, Zhuming; US2012/46306; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem