At the same time, in my other blogs, there are other synthetic methods of this type of compound,625-92-3, 3,5-Dibromopyridine, and friends who are interested can also refer to it.
Synthetic Route of 625-92-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 625-92-3, name is 3,5-Dibromopyridine. A new synthetic method of this compound is introduced below.
Intermediate G5: 5-Ethylpyridine-3-boronic acid; Step 1: 3-Bromo-5-ethyl-pyridine; 3,5-dibromo-pyridine (0.4 g, 1.688 mmol), potassium carbonate (0.7 g, 5.064 mmol), [1,1′- Bis(diphenylphosphino)ferrocene]palladium(II) chloride (0.138 g, 0.169 mmol), silver(I)oxide (0.902 g, 4.22 mmol), ethyl boronic acid (0.150 g, 2.03 mmol) and THF (8 ml) are mixed together, purged with argon and heated to reflux overnight. After cooling to room temperature the reaction mixture is filtered through Celite (filter agent) washing with DCM. The DCM is reduced in vacuo and the residue is purified by flash chromatography by loading onto a 20 g silica column eluting with DCM to afford the title compound, [MH+ 185.91 and 187.91].
At the same time, in my other blogs, there are other synthetic methods of this type of compound,625-92-3, 3,5-Dibromopyridine, and friends who are interested can also refer to it.
Reference:
Patent; NOVARTIS AG; LEGRAND, Darren, Mark; WO2009/10530; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem