The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 626-55-1, name is 3-Bromopyridine. This compound has unique chemical properties. The synthetic route is as follows. 626-55-1
Synthesis of 3-(4-Methoxyphenyl)pyridine (30) via Scheme 5; A mixture of 3-bromopyridine, (29, 190 mg, 1.20 mmol), 4- methoxyphenylboronic acid (152 mg, 1.00 mmol), Pd(PPh3 )4 (35.0 mg, 0.0300 mmol) and K3PO4 (430 mg, 2.00 mmol) in 1 ,4-dioxane (10 mL) was heated at 100 0C for 18 h. The solvent was removed under reduced pressure and ethyl acetate was added to the solid residue. The organic layer was washed sequentially with water, brine, and then dried over anhydrous Na2SO4. Concentration of the filtrate followed by chromatography [silica, hexanes/ethyl acetate (3: 1 )] gave 30 as a white solid (108 mg, 58% yield), mp 61-63 0C. 1 H NMR (500 MHz, CDCl3) delta 3.86 (s, 3H), 7.01 (d, J = 8.5 Hz, 2H), 7.33 (dd, J = 5.0, 8.0 Hz, 1 H), 7.52 (d, J = 8.5 Hz, 2H), 7.81-7.83 (m, 1 H), 8.54 (dd, J = 2.0, 5.0 Hz, 1 H), 8.81 (br s, 1 H).
Statistics shows that 626-55-1 is playing an increasingly important role. we look forward to future research findings about 3-Bromopyridine.
Reference:
Patent; THE GENERAL HOSPITAL CORPORATION; THE BRIGHAM AND WOMEN’S HOSPITAL, INC.; WO2009/114180; (2009); A1;,
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