Extracurricular laboratory: Synthetic route of 63071-10-3

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,63071-10-3, its application will become more common.

Reference of 63071-10-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 63071-10-3 as follows.

[0360] A suspension OfMnO2 (7.3 g, 84 mmol) and (4-chloro-pyrindin-2-yl)methanol(1 g, 7 mmol) in CHCl3 was heated to refulx for 90 minutes. The mixture was filtered though a layer of Celite and concentrated in vacuo to afford 520 mg of 4-chloropicolinaldehyde as a white solid. HPLC 1.8 minutes and MS 142 as M=I peak.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,63071-10-3, its application will become more common.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2008/106139; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem