The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6854-07-5, name is 5-Nitro-2-oxo-3-pyridinecarboxylic Acid. This compound has unique chemical properties. The synthetic route is as follows. Formula: C6H4N2O5
4b) 2-Chloro-5-nitropyhdin-3-yl phenyl ketone; 18.4 g of the acid prepared in example 4a) is admixed at 25C with 120 ml of thionyl chloride followed by 3 ml of DMF, and subsequently heated at reflux for 3 hours. The excess thionyl chloride is removed under reduced pressure and the yellow solid that remains is dissolved in 100 ml of benzene. This solution is admixed with 4O g of AICI3 at 00C and then stirred at 25C for 16 hours. The reaction mixture is then poured cautiously into cold (partly frozen) concentrated hydrochloric acid; after one hour the mixture is filtered and the organic phase is separated off. The organic phase is washed with hydrochloric acid, dried over sodium sulfate, filtered and concentrated under reduced pressure. The resulting residue is purified by chromatography on silica gel with hexane/10% ethyl acetate. This gives 15 g of the title compound. NMR (300 MHz, DMSO-d6): delta = 7.60 (2H), 7.77 (1 H), 7.87 (2H), 8.95 (1 H), 9.4 (1 H).
With the rapid development of chemical substances, we look forward to future research findings about 6854-07-5.
Reference:
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; BAYER HEALTHCARE AKTIENGESELLSCHAFT; WO2009/30725; (2009); A2;,
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