69045-84-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 69045-84-7, name is 2,3-Dichloro-5-(trifluoromethyl)pyridine. A new synthetic method of this compound is introduced below.
(R) -2- (4-hydroxyphenoxy) propionic acid (3 g),DMF (35 ml), slowly adding K2CO3 (4.55 g),Heating up to 70 ~ 80 ,Stir for 1h,Was added dropwise 2,3-dichloro-5-trifluoromethylpyridine (3.56 g)Keep at 70 ~ 80 for 8h,Stop the reaction,Naturally cooled to room temperature,The mixture was poured into ice water (200 mL)The pH was adjusted to 4 to 5 using dilute hydrochloric acid, extracted with ethyl acetate,Organic phase washed,dry,(R) -2- [4- (5-trifluoromethyl-3-chloropyridin-2-yloxy) phenoxy]Propionic acid brown liquid 5.03 g,Yield 84.4%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,69045-84-7, 2,3-Dichloro-5-(trifluoromethyl)pyridine, and friends who are interested can also refer to it.
Reference:
Patent; China Three Gorges University; Liu Qixing; Zhou Haifeng; Lu Guoren; Peng Yuqi; (9 pag.)CN106632293; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem