Adding a certain compound to certain chemical reactions, such as: 7477-10-3, 6-Chloro-5-nitronicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 6-Chloro-5-nitronicotinic acid, blongs to pyridine-derivatives compound. Application In Synthesis of 6-Chloro-5-nitronicotinic acid
General procedure: SI, Figure 1. General procedure for the synthesis of the ester compounds (2, Scheme 1). To the commercially available acids (1a-c) (1 equiv.) in dry DCM (20 mL) was added DMAP (1 equiv.),DCC (1.2 equiv.) and various alcohols (1.2 equiv.) at 0 oC. The mixture was stirred at 0 oC for 1h then at room temperature for 17 h. The solvent was evaporated and the residue was purified by flash column chromatography on silica gel using a mixture of solvent of hexane: ethylacetate (10:1) to provide the desired ester derivatives(2).
The synthetic route of 7477-10-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Iniguez, Eva A.; Perez, Andrea; Maldonado, Rosa A.; Skouta, Rachid; Bioorganic and Medicinal Chemistry Letters; vol. 25; 22; (2015); p. 5315 – 5320;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem