Reference of 848498-98-6 ,Some common heterocyclic compound, 848498-98-6, molecular formula is C8H8Cl2N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
[0365] l-(2,6-Dichloro-4-pyridinyl)ethanone (156). A solution of MeMgBr (3 M in Et2O, 4.3 mL, 12.8 mmol) was added slowly to a stirred solution of amide 155 (2.0 g, 8.5 mmol) in dry THF (40 mL) at 0 0C and the mixture was stirred at 0 0C for 3 h. The reaction mixture was quenched with aq. NH4Cl solution (15 mL) and the mixture extracted with EtOAc (3 x 50 mL). The combined organic fraction was washed with water (50 mL), washed with brine (50 mL), dried and the solvent evaporated. The crude product was recrystallized to give the ketone 156 as white crystals (1.61 g, 99%): mp (EtOAc) 50-51 C; 1H NMR (CDCl3) delta 7.68 (s, 2 H, H- 3′, H-5′), 2.61 (s, 3 H, H-2); MS m/z 190.4, 192.4 (MH+, 100, 70%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 848498-98-6, 2,6-Dichloro-N-methoxy-N-methylisonicotinamide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY; AUCKLAND UNISERVICES LIMITED; WO2009/114552; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem