Related Products of 872355-64-1 , The common heterocyclic compound, 872355-64-1, name is 1H-Pyrrolo[3,2-b]pyridine-5-carboxylic acid, molecular formula is C8H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Preparation of compound 9a: 3-iodo-lH-pyrrolo[3,2-b]pyridine-5-carboxylic acidTo a solution of lH-pyrrolo[3,2-b]pyridine-5-carboxylic acid (0.400 g, 2.467 mmol, Adesis, New Castle, DE) in DMF (4.9 mL) was added I2 (0.626 g, 2.467 mmol) and KOH (0.346 g, 6.17 mmol). The mixture was stirred at RT for 1 h. The mixture was poured into ice and H20 (30 mL) containing sodium bisulfite (0.257 g, 2.467 mmol). The reaction was acidified with 5 M HCl. A yellow solid precipitated out and was collected by filtration, washed with H20 and dried overnight in a vacuum oven to give 3-iodo-lH- pyrrolo[3,2-b]pyridine-5-carboxylic acid (0.516 g, 1.791 mmol, 72.6 % ). MS (ESI, pos. ion) m/z: 289.0 (M+l). .H NMR (400 MHz, DMSO-d6) delta ppm 7.91 (2 H, s), 8.01 (1 H, d, J=2.74 Hz), 12.03 – 12.11 (1 H, m).
The synthetic route of 872355-64-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AMGEN INC.; WANG, Hui-Ling; CEE, Victor, C.; HERBERICH, Bradley, J.; JACKSON, Claire, L., M.; LANMAN, Brian, Alan; NIXEY, Thomas; PETTUS, Liping, H.; REED, Anthony, B.; WU, Bin; WURZ, Ryan; TASKER, Andrew; WO2012/129338; (2012); A1;,
Pyridine – Wikipedia,
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