Application of 98027-80-6, Adding some certain compound to certain chemical reactions, such as: 98027-80-6, name is 4-Bromo-2,6-dichloropyridine,molecular formula is C5H2BrCl2N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 98027-80-6.
To a de-gassed mixture of 3-CHLORO-4-FLUOROPHENYLBORONIC acid (77 mg, 0. 44 MMOL)), 4-bromo-2, 6-dichloro-pyridine (Talik and Plazek (1959) ROCZ. CHENT. 33 : 387-92 ; 100 mg, 0. 44 mmol), and 2M Na2CO3 (0. 55 MMOL), in DME (4mL) under nitrogen, add Pd (PPh3) 4 (0. 026 MMOL). Stir the mixture at 80C overnight, concentrate, and extract with EtOAc. Dry over NA2S04, concentrate under vacuum, and purify by preparative TLC (9 : 1 hexanes/EtOAc) to give 2, 3-DICHLORO-4- (3-CHLORO-4-FLUORO-PHENYL)-PYRIDINE.
According to the analysis of related databases, 98027-80-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NEUROGEN CORPORATION; WO2005/7648; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem