Electric Literature of 885276-93-7, Adding some certain compound to certain chemical reactions, such as: 885276-93-7, name is Ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylate,molecular formula is C10H9BrN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 885276-93-7.
Synthesis of Exemplary CompoundsSynthesis of ethyl 5-{{2R,4S)-4-fluoro-2-(3-fluoroDhenyl)Dyrrolidin-1-yl)Dyrazolo[1 ,5- -3-carboxylate (X- 1)[000300] A N2 purged flask was charged with ethyl 5-bromopyrazolo[1 ,5-a]pyridine-3- carboxylate (27 mg, 0.1 mmol), tris(dibenzylideneacetone)dipalladium(0) (2 mg, 2 muiotaetaomicronIota), xantphos (5 mg, 8 muiotaetaomicronIota), cesium carbonate (46 mg, 0.14 mmol), 1 ,4-dioxane (0.5 ml_) and (2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidine (1-6) (18 mg, 0.1 mmol). The contents were heated to 120 C for 12 hours. Upon cooling to room temperature the reaction was partitioned with EtOAc and water. The organic layer was washed with water, brine, dried over magnesium sulfate, filtered and reduced to dryness. The crude product was purified by column chromatography on silica gel withEtOAc/hexanes gradient as eluant to yield ethyl 5-((2R,4S)-4-fluoro-2-(3- fluorophenyl)pyrrolidin-1 -yl)pyrazolo[1 ,5-a]pyridine-3-carboxylate (X-1 ). 1 H NMR (400MHz, CDCI3) delta 8.20 (s, 1 H), 8.16 (d, J = 7.6 Hz, 1 H), 7.31 (td, J = 5.6, 7.6 Hz, 1 H), 7.05 (d, J = 7.6 Hz, 1 H), 6.98 (d, J = 2.8 Hz, 1 H), 6.96 – 6.91 (m, 2 H), 6.24 (dd, J = 2.8, 8.0 Hz, 1 H), 5.39 (d, J = 52.8 Hz, 1 H), 5.04 (dd, J = 7.2, 9.2 Hz, 1 H), 4.34 – 4.26 (m, 2 H), 4.17 – 3.90 (m, 2 H), 2.93 – 2.81 (m, 1 H), 2.1 1 (dddd, J = 3.6, 9.2, 13.2, 40.8 Hz, 1 H). MS m/z 372.1 (M+1 )+.
According to the analysis of related databases, 885276-93-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; IRM LLC; MOLTENI, Valentina; FAN, Yi; LOREN, Jon; SMITH, Jeffrey M.; FLATT, Brenton T.; WO2012/116217; (2012); A1;,
Pyridine – Wikipedia,
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