Extracurricular laboratory: Synthetic route of N,N-Dimethylnicotinamide

According to the analysis of related databases, 6972-69-6, the application of this compound in the production field has become more and more popular.

Electric Literature of 6972-69-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6972-69-6, name is N,N-Dimethylnicotinamide. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of docetaxel [501](0.075 g, 0.093 mmol, 1.0 eq) in ACN (5 ml) was added Nal (0.055 g, 0.372 mmol, 4.0 eq) and Nu,Nu-dimethyl nicotinamide (0.023 g, 0.186 mmol, 2.0 eq) at RT. The reaction mixture was 60C over night. Solvent was removed under vacuum, solid residue taken in DCM, inorganic impurities filtered off, DCM removed under vacuum and the product triturated with ether, filtered and vacuum dried to get the product [502].

According to the analysis of related databases, 6972-69-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SPHAERA PHARMA PVT. LTD; DUGAR, Sundeep; MAHAJAN, Dinesh; HOLLINGER PETER, Frank; WO2012/137225; (2012); A1;,
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