In 2022,Fan, Jiang-Tao; Fan, Xin-Heng; Gao, Cai-Yan; Wei, Jinchao; Yang, Lian-Ming published an article in Organic Chemistry Frontiers. The title of the article was 《Regioselectively switchable alkyne cyclotrimerization catalyzed by a Ni(II)/bidentate P-ligand/Zn system with ZnI2 as an additive》.Computed Properties of C7H5N The author mentioned the following in the article:
A simple catalytic system of Ni(PPh3)2Cl2/dppb or dppm/Zn can effect an efficient and regioselectively controlled alkyne cyclotrimerization to form 1,2,4- (with no additive) or 1,3,5-regioisomers (with the use of a ZnI2 additive). This protocol features the advantages of facile manipulation, mild conditions, broad substrate scope, high yields, excellent functional-group tolerance and easily controllable regioselectivity, and demonstrates practical potential for the construction of complicated and well-defined poly-substituted benzene derivatives The mechanistic studies were carried out preliminarily. In addition to this study using 4-Ethynylpyridine, there are many other studies that have used 4-Ethynylpyridine(cas: 2510-22-7Computed Properties of C7H5N) was used in this study.
4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Computed Properties of C7H5N