In 2022,Fan, Weibin; Zhang, Yuan; Li, Yinghua; Zhang, Wei; Huang, Deguang published an article in ChemSusChem. The title of the article was 《Solvent-Free Strategy for Direct Access to Versatile Quaternary Ammonium Salts with Complete Atom Economy》.Computed Properties of C7H7NO The author mentioned the following in the article:
A solvent-free method for the synthesis of quaternary ammonium salts (QAS) such as 1-(2-Iodo-1-phenylethyl)-4-pyridinium triiodide I [R1 = Ph, 4-MeC6H4, 2-ClC6H4, etc.; R2 = H, 4-OMe, 4-C(O)OMe, etc.; X = H, N; Y = H, N] by iodoquaternization of alkenes with N-heteroarenes was reported. Its advantages lied in energy-saving and clean production by using iodine as the oxidant and manual grinding the starting materials, together with the complete atom economy and low process mass intensity (PMI) value. Generated QAS converted to pyrroles such as II [R1 = Ph, 4-MeC6H4, 2-ClC6H4, etc.; R2 = 5-SMe, C(O)Ome, C(O)Ph, etc.]. Demonstrated by 50 examples, the generated QAS was proved to be able to produce valuable chems., such as biol. protease inhibitors, anti-cancer agents, and organic fluorescent materials. In the experimental materials used by the author, we found 4-Acetylpyridine(cas: 1122-54-9Computed Properties of C7H7NO)
4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Computed Properties of C7H7NO