On July 21, 2022, Fasching, Bernhard; Ryckmans, Thomas; Flohr, Alexander; Ritzen, Andreas; Harvey, Freya; McAllister, Laura published a patent.Recommanded Product: 6-(tert-Butyl)pyridin-3-amine The title of the patent was Preparation of isoindolinone compounds as modulators of cereblon. And the patent contained the following:
This invention relates to the title compounds I [X1 = (un)substituted alkyl, cycloalkyl, aryl, etc.; or X1 together with the N atom of the carbamate forms (un)substituted 4-8 membered heterocycloalkyl; X2 = H, (un)substituted cycloalkyl, aryl, etc.; L1 = a covalent bond, alkyl; L2 = a covalent bond, alkyl; L3 = a covalent bond, alkyl, O, etc.] or pharmaceutically acceptable salts or stereoisomers thereof, useful as modulators of cereblon, in particular in the treatment of abnormal cell growth in mammals, especially humans. E.g., a multi-step synthesis of II, starting from Me 5-bromo-2-methylbenzoate, was described. Exemplified compounds I were tested for their ability for cereblon binding (data given for representative compounds I). Pharmaceutical composition comprising compound I was disclosed. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).Recommanded Product: 6-(tert-Butyl)pyridin-3-amine
The Article related to isoindolinone dioxopiperidinyl preparation cereblon modulator anticancer, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Recommanded Product: 6-(tert-Butyl)pyridin-3-amine