Formula: C7H5NIn 2019 ,《Screening of Three Transition Metal-Mediated Reactions Compatible with DNA-Encoded Chemical Libraries》 was published in Helvetica Chimica Acta. The article was written by Favalli, Nicholas; Bassi, Gabriele; Zanetti, Tania; Scheuermann, Joerg; Neri, Dario. The article contains the following contents:
The construction of DNA-encoded chem. libraries (DECLs) crucially relies on the availability of chem. reactions, which are DNA-compatible and which exhibit high conversion rates for a large number of diverse substrates. In this work, we present our optimization and validation procedures for three copper and palladium-catalyzed reactions (Suzuki cross-coupling, Sonogashira cross-coupling, and copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC)), which have been successfully used by our group for the construction of large encoded libraries. The results came from multiple reactions, including the reaction of 4-Ethynylpyridine(cas: 2510-22-7Formula: C7H5N)
4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Formula: C7H5N