Felts, Andrew S. published the artcileDiscovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety, Recommanded Product: 4-Amino-2-picoline, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(21), 5779-5785, database is CAplus and MEDLINE.
Development of SAR in an aryl ether series of mGlu5 NAMs leading to the identification of tool compound VU0409106 is described in this Letter. VU0409106 is a potent and selective neg. allosteric modulator of mGlu5 that binds at the known allosteric binding site and demonstrates good CNS exposure following i.p. dosing in mice. VU0409106 also proved efficacious in a mouse marble burying model of anxiety, an assay known to be sensitive to mGlu5 antagonists as well as clin. efficacious anxiolytics.
Bioorganic & Medicinal Chemistry Letters published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Recommanded Product: 4-Amino-2-picoline.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem