Feng, Danqing et al. published their research in ACS Medicinal Chemistry Letters in 2018 | CAS: 203794-33-6

5,6-Dichloro-3-nitropyridin-2-amine (cas: 203794-33-6) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C閳ユ弻 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Product Details of 203794-33-6

Discovery of MK-8722: A Systemic, Direct Pan-Activator of AMP-Activated Protein Kinase was written by Feng, Danqing;Biftu, Tesfaye;Romero, F. Anthony;Kekec, Ahmet;Dropinski, James;Kassick, Andrew;Xu, Shiyao;Kurtz, Marc M.;Gollapudi, Anantha;Shao, Qing;Yang, Xiaodong;Lu, Ku;Zhou, Gaochao;Kemp, Daniel;Myers, Robert W.;Guan, Hong-Ping;Trujillo, Maria E.;Li, Cai;Weber, Ann;Sebhat, Iyassu K.. And the article was included in ACS Medicinal Chemistry Letters in 2018.Product Details of 203794-33-6 This article mentions the following:

5′-Adenosine monophosphate-activated protein kinase (AMPK) is a key regulator of mammalian energy homeostasis and has been implicated in mediating many of the beneficial effects of exercise and weight loss including lipid and glucose trafficking. As such, the enzyme has long been of interest as a target for the treatment of Type 2 Diabetes Mellitus. The authors describe the optimization of 灏?-selective, liver-targeted AMPK activators and their evolution into systemic pan-activators capable of acutely lowering glucose in mouse models. Identifying surrogates for the key acid moiety in early generation compounds proved essential in improving 灏?-activation and in balancing improvements in plasma unbound fraction while avoiding liver sequestration. In the experiment, the researchers used many compounds, for example, 5,6-Dichloro-3-nitropyridin-2-amine (cas: 203794-33-6Product Details of 203794-33-6).

5,6-Dichloro-3-nitropyridin-2-amine (cas: 203794-33-6) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C閳ユ弻 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Product Details of 203794-33-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem