Feng, Yufei published the artcileRelative bioavailability of betahistine mesylate tablet in healthy volunteers, Related Products of pyridine-derivatives, the publication is Zhongguo Linchuang Yaolixue Zazhi (2006), 22(3), 188-191, database is CAplus.
The bioavailability of domestic and imported betahistine mesylate and its bioequivalence in healthy volunteers were studied. A single oral dose of 24 mg domestic and imported betahistine mesylate tablets were given to 20 healthy male volunteers according to an open randomized 2 way crossover design. Plasma concentration of betahistine mesylate was determined by HPLC-MS-MS method. The pharmacokinetic parameter of the two products were as follow: tmax were (1.1 ± 0.5) and (1.0 ± 0.4) h; Cmax were (358.88 ± 93.44) and (360.99 ± 62.88) ng/mL-1; AUC0-t were (1687.01 ± 400.51) and (1591.43 ± 352.05) ng/h/mL-1, resp. The relative bioavailability of domestic product was (108.3 ± 24.1)%. The result demonstrated that two formations were bioequivalence by anal. of variance, two-one side test and 90% confidential internal.
Zhongguo Linchuang Yaolixue Zazhi published new progress about 54856-23-4. 54856-23-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Amine,Inhibitor,Inhibitor, name is N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, and the molecular formula is C10H20N2O6S2, Related Products of pyridine-derivatives.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem