SDS of cas: 13534-97-9In 2012 ,《Design, synthesis and structure-activity-relationship of 1,5-tetrahydronaphthyridines as CETP inhibitors》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Fernandez, Maria-Carmen; Escribano, Ana; Mateo, Ana I.; Parthasarathy, Saravanan; Martin de la Nava, Eva M.; Wang, Xiaodong; Cockerham, Sandra L.; Beyer, Thomas P.; Schmidt, Robert J.; Cao, Guoqing; Zhang, Youyan; Jones, Timothy M.; Borel, Anthony; Sweetana, Stephanie A.; Cannady, Ellen A.; Stephenson, Gregory; Frank, Scott; Mantlo, Nathan B.. The article contains the following contents:
This Letter describes the discovery and SAR optimization of 1,5-tetrahydronaphthyridines, a new class of potent CETP inhibitors. The effort led to the identification of I and II with in vitro human plasma CETP inhibitory activity in the nanomolar range (IC50 = 23 and 22 nM, resp.). Both I and II exhibited robust HDL-c increase in hCETP/hApoA1 dual heterozygous mice model. In addition to this study using 6-Bromopyridin-3-amine, there are many other studies that have used 6-Bromopyridin-3-amine(cas: 13534-97-9SDS of cas: 13534-97-9) was used in this study.
6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.SDS of cas: 13534-97-9