Condensation of substituted 2-aminopyridine with β-keto carboxylic esters: 4H-pyrido[1,2-a]pyrimidin-4-ones and pyridin-2-ones was written by Ferrarini, Pier Luigi;Mori, Claudio;Manera, Clementina;Mori, Filippo;Calderone, Vincenzo;Martinotti, Enrica. And the article was included in Journal of Heterocyclic Chemistry in 1999.Synthetic Route of C7H9N3O This article mentions the following:
The condensation of substituted 2-aminopyridines 5 with β-keto carboxylic esters in polyphosphoric acid is reported. In addition to the target compounds, 4H-pyrido[1,2-a]pyrimidin-4-ones, 1-(2-pyridinyl)-2-pyridinones were also obtained in this reaction. The latter compounds were tested for their Ca-antagonistic activity but failed to evoke any vasorelaxant response. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Synthetic Route of C7H9N3O).
N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Synthetic Route of C7H9N3O