Synthesis of heteroarylsulfanyl- and heteroaryloxyfuroxans by nucleophilic substitution of nitro group in nitrofuroxans with heterocyclic thiol and hydroxy derivatives* was written by Fershtat, Leonid L.;Epishina, Margarita A.;Kulikov, Alexander S.;Struchkova, Marina I.;Makhova, Nina N.. And the article was included in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2015.Recommanded Product: 15128-90-2 This article mentions the following:
A general method for the synthesis of heteroaryl- and heteroaryloxyfuroxans, e.g., I, based on nucleophilic substitution of 4-nitrofuroxans with heterocyclic thiols and alcs. in 1,8-diazabicyclo[5.4.0]undec-7-ene/MeCN system at room temperature is reported. Hetarylthiols reacted with 4-nitrofuroxans containing aliphatic, benzyl, and aromatic substituents at the ring C-3 atom, allowing to obtain a library of heteroarylsulfanylfuroxans, while the reaction with hydroxy heterocycles was successful only in the case of 4-nitro-3-phenylfuroxan, the rest of the nitrofuroxans showing low reactivity, and substitution products could be obtained only in certain cases. 4-Nitrofuroxans with electron-withdrawing substituents (NO2, CONH2) acted as oxidants, forming 1,2-di(heteroaryl)disulfides. In the experiment, the researchers used many compounds, for example, 3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2Recommanded Product: 15128-90-2).
3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C閳ユ弻 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: 15128-90-2