Regioselective cyanation of pyridine 1-oxides with trimethylsilanecarbonitrile: a modified Reissert-Henze reaction was written by Fife, Wilmer K.. And the article was included in Journal of Organic Chemistry in 1983.Application of 1620-76-4 This article mentions the following:
Pyridine 1-oxide and its 2- and 4-Me derivatives are converted in nearly quant. yield to the corresponding 2-pyridinecarbonitrile by treatment with equivalent amounts of Me3SiCN and Me2NCOCl in CH2Cl2. Similarly, 3-methylpyridine 1-oxide is converted to a mixture of 3-methyl-2-pyridinecarbonitrile (90%) and 5-methyl-2-pyridinecarbonitrile (5%). In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Application of 1620-76-4).
4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Application of 1620-76-4