Rodriguez, Anabel M.; Molina, Francisco; Diaz-Requejo, M. Mar; Perez, Pedro J. published the article 《Copper-Catalyzed Selective Pyrrole Functionalization by Carbene Transfer Reaction》. Keywords: pyrrole preparation carbene transfer reaction copper catalyst.They researched the compound: 2,4-Dimethyl-1H-pyrrole( cas:625-82-1 ).Application of 625-82-1. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:625-82-1) here.
1H-Pyrroles can be directly functionalized by means of the incorporation of carbene groups from diazo compounds, in a process catalyzed by TpxCu complexes (Tpx=hydrotrispyrazolylborate ligand). The reactions take place with a complete selectivity toward the formal insertion of the carbene into the Cα-H bond, leading to alkylated pyrroles, with no modification of the Cβ-H, N-H or C=C bonds of the pyrrole unit. Alkyl substituents at C-ring as well as alkyl, aryl, allyl or alkyne substitution at N atom are tolerated, the strategy affording 20 new pyrrole derivatives The observance of partial deuteration at the methylene group when the reaction is carried out with added D2O serves to discard the direct insertion of the carbene group into the Csp2-H bond, the alternative electrophilic attack to the pyrrole ring being feasible.
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