Barut, Burak; Coban, Ozlem; Yalcin, Can Ozgur; Bas, Huseyin; Sari, Suat; Biyiklioglu, Zekeriya; Demirbas, Umit; Ozel, Arzu published an article about the compound: 2,4-Dimethyl-1H-pyrrole( cas:625-82-1,SMILESS:CC1=CNC(C)=C1 ).Category: pyridine-derivatives. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:625-82-1) through the article.
A new series of BODIPY 3 and 6 with two dimethylamino and diethylamino moieties at their 3,5-positions were prepared via Knoevenagel condensation of BODIPY 2 and 5 with 3,4-bis{3-[3-(dimethylamino)phenoxy]propoxy}benzaldehyde and 4-{3-[3-(dimethylamino)phenoxy]propoxy}benzaldehyde. Water soluble BODIPY-3a and BODIPY-6a were synthesized by treating BODIPY 3 and 6 with an excess of CH3-I in DMF. Singlet oxygen quantum yields, DNA binding and cleavage, topoisomerase II inhibition and photodynamic therapy activities of two cationic BODIPY derivatives (BODIPY-3a and BODIPY-6a) were examined utilizing different methods. The singlet oxygen quantum yield values of compounds were found to be 0.07 and 0.13 in TBS. BODIPY-3a and BODIPY-6a interacted with CT-DNA with Kb values of 5.18±(0.15) × 103 and 2.88±(0.05) × 103 M-1, resp. The agarose gel electrophoresis experiments indicated that BODIPY-3a and BODIPY-6a had marked photocleavage activities on supercoiled plasmid DNA. The topoisomerase II inhibition studies showed that BODIPY-6a had higher inhibitory effect than BODIPY-3a, which was in line with the theor. DNA-topoisomerase complex binding studies via mol. docking method. Based on MTT assay results, the IC50 values of BODIPY-3a and BODIPY-6a ranged from > 100μM to 27.20μM for 24, 48 and 72 h without and with light irradiation Finally, LpBODIPY-6a and NpBODIPY-6a were prepared and their cytotoxic and phototoxic properties were determined using MTT assay. The IC50 values of LpBODIPY-6a were found > 100μM and 33.63μM, while the IC50 values of NpBODIPY-6a were 26.01μM and 5.66μM without/with irradiation The presented studies suggested that nanoparticle formulation was found the most promising delivery vehicle for BODIPY-6a.
In addition to the literature in the link below, there is a lot of literature about this compound(2,4-Dimethyl-1H-pyrrole)Category: pyridine-derivatives, illustrating the importance and wide applicability of this compound(625-82-1).