Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 625-82-1, is researched, Molecular C6H9N, about Heavy atom substituted near-infrared BODIPY nanoparticles for photodynamic therapy, the main research direction is heavy atom IR BODIPY nanoparticle photodynamic therapy.Synthetic Route of C6H9N.
Photodynamic therapy (PDT) is a promising alternative to cancer therapy for its non-invasive advantage. The rational design of ideal photosensitizers (PSs) is especially significant in PDT. Herein, we synthesized a diiodo-substituted BODIPY (SNBDP) with near-IR (NIR) region absorption and fluorescence emission by Knoevenagel condensation reaction. The SNBDP nanoparticles (NPs) were prepared by the nanopptn. method wrapped by poloxamer. As-prepared SNBDP NPs exhibited robust water stability and notable photostability. After cellular endocytosis, the NPs could elicit excellent cancer-killing effects with a low half maximal inhibitory concentration (10.55μM for HeLa and 13.46μM for A549 cells) due to good singlet oxygen quantum yield (ΦΔ = 40%) of PS derived from the heavy atom effect. Moreover, the favorable cancer cell inhibition efficacy could efficiently reduce the dark toxicity of drug. We believe this ingenious design could provide a reference value for the exploration of optimal PS for PDT.
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