Franco, Marina; Jasionowska, Renata published an article in 2013, the title of the article was Quick single run Capillary Zone Electrophoresis determination of active ingredients and preservatives in pharmaceutical products.Product Details of 132-20-7 And the article contains the following content:
The paper deals with the development of a rapid and efficient Capillary Zone Electrophoresis (CZE) method for Quality Control anal. of pharmaceutical preparations containing antihistamines, decongestants, anticholinergic remedies and preservatives. Active ingredients of interest are: ChlorPheniramine Maleate (CPM), DiPhenhydramine Hydrochloride (DPH), Ephedrine hydrochloride (E), Isopropamide Iodide (II), Pheniramine Maleate (PM), Lidocaine hydrochloride (L), Tetracaine hydrochloride (T), Clopamide Hydrochloride (CH) , DiHydroErgochristine (DHE), PhenylEphrine hydrochloride (PE) and Acetaminophen (A). Preservatives studied are: MethylParaben (MeP), EthylParaben (EtP), PropylParaben (PrP), ButylParaben (BuP), p-HydroxyBenzoic Acid (p-HBA). All these analytes were separated in a single run using 60 mM tetraborate buffer solution (TBS) pH = 9.2 as a BackGround Electrolyte (BGE) by an uncoated fused silica capillary of I.D. = 50 μm and applying a voltage of 25 kV in the first part of the electrophoretic run (up to 5.8 min) and 30 kV for the remaining time. The hydrodynamic pressurization of the inlet vial was 20 psi at 7.2 min. up to the end of anal. Total separation time was of 7.5 min. The method was then successfully validated and applied to the simultaneous determination of active ingredients and preservatives. Good repeatability, linearity, and sensitivity were demonstrated. Precision of migration time ™ was RSD% <0.53% and of corrected peak area (Ac) was RSD% <6.15%. The linearity evaluation gave 0.9928 < r2 < 1.000. LOD and LOQ, accuracy (recovery) and ruggedness were evaluated for each analyte demonstrating the good reliability of the method. Analyses of some pharmaceutical real samples were performed. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Product Details of 132-20-7
The Article related to pharmaceutical preservative analysis capillary zone electrophoresis, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Product Details of 132-20-7