Frolov, Nikita; Detusheva, Elena; Fursova, Nadezhda; Ostashevskaya, Irina; Vereshchagin, Anatoly published the artcile< Microbiological Evaluation of Novel Bis-Quaternary Ammonium Compounds: Clinical Strains, Biofilms, and Resistance Study>, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride, the main research area is clin strains biofilms microbiologica novel bis quaternary ammonium compound; antibacterial activity; antibiofilm activity; antiseptics; bacterial resistance; biocides; disinfectants; pyridinium salts; quaternary ammonium compounds.
This work is devoted to the investigation of biocidal properties of quaternary ammonium compounds (QACs) based on pyridine structures with aromatic spacers, and their widely known analogs, against clin. significant microorganisms. This study is focused on investigating their antimicrobial activity (min. inhibitory concentrations (MICs) and min. bactericidal concentrations (MBCs)), antibiofilm properties (min. biofilm inhibitory concentrations (MBICs) and min. biofilm eradication concentrations (MBECs)), synergetic effect with different alcs. in antiseptic formulations, and bacterial resistance development. It was shown that all combined analog preparations had a higher level of antibacterial activity against the tested bacterial strains, with a 16- to 32-fold reduction in MICs and MBCs compared to previously used antiseptic preparations Moreover, hit-QACs demonstrated a stable effect against Gram-neg. E. coli, K. pneumoniae, and A. baumannii within a month of incubation. Overall results indicated a high level of antibacterial activity of pyridine-based QACs.
Pharmaceuticals published new progress about Acinetobacter baumannii. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride.