On March 31, 2003, Frosini, Maria; Sesti, Casilde; Dragoni, Stefania; Valoti, Massimo; Palmi, Mitri; Dixon, Henry B. F.; Machetti, Fabrizio; Sgaragli, Giampietro published an article.SDS of cas: 636-73-7 The title of the article was Interactions of taurine and structurally related analogues with the GABAergic system and taurine binding sites of rabbit brain. And the article contained the following:
The aim of this study was to find taurinergic compounds that do not interact with brain GABAergic systems. Washed synaptic membranes (SM) from whole rabbit brain were able to bind [3H]muscimol. Saturation experiments of the binding of [3H]GABA to GABAB receptors showed that SM possess two binding components; twice Triton X-100-treated SM contained 0.048 mmol endogenous taurine/kg protein and bound [3H]taurine in a saturable manner (Kd = 249.0 nM and Bmax = 3.4 pmol mg-1 prot). Among the 19 structural analogs of taurine, 6-aminomethyl-3-methyl-4H-1,2,4-benzothiadiazine 1,1-dioxide (TAG), 2-aminoethylarsonic (AEA), 2-hydroxyethanesulfonic (ISE) and (±)cis-2-aminocyclohexane sulfonic acids (CAHS) displaced [3H]taurine binding (Ki = 0.13, 0.13, 13.5 and 4.0 μM, resp.). These analogs did not interact with GABAA and GABAB receptors and did not affect taurine- and GABA-uptake systems and GABA-transaminase activity. 3-Aminopropanesulfonic acid (OMO), β-alanine, pyridine-3-sulfonic acid, N,N,N-trimethyltaurine (TMT), 2-(guanidino)ethanesulfonic acid (GES), ethanolamine-O-sulfate, N,N-dimethyltaurine (DMT), taurine and (±)piperidine-3-sulfonic acid (PSA) inhibited [3H]muscimol binding to GABAA receptors with different affinities (Ki = 0.013, 7.9, 24.6, 47.5, 52.0, 91.0, 47.5, 118.1 and 166.3 μM, resp.). Taurine, 2-aminoethylphosphonic acid, DMT, TMT and OMO inhibited the binding of [3H]GABA to GABAB receptors with Ki’s in the μM range (0.8, 3.5, 4.4, 11.3 and 5.0, resp.). GES inhibited taurine uptake (IC50 = 3.72 μM) and PSA GABA transaminase activity (IC50 = 103.0 μM). In conclusion, AEA, TAG, ISE and CAHS fulfill the criteria for taurinergic agents. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).SDS of cas: 636-73-7
The Article related to taurine analog gabaergic system receptor brain, Mammalian Hormones: Neurotransmitters and other aspects.SDS of cas: 636-73-7