Frydman, Benjamin published the artcilePyrroles from azaindoles. Synthesis of porphobilinogen and related pyrroles, Recommanded Product: Ethyl 5-methoxy-1H-pyrrolo[2,3-c]pyridine-2-carboxylate, the main research area is porphobilinogen pyrrole; pyrrole porphobilinogen.
A new method for the synthesis of 2-aminomethyl-3-pyrroleacetic acids is described. The condensation of 2-methoxy- and 2-benzyloxy-4-methyl-5-nitropyridine with diethyl oxalate afforded the corresponding Et o-nitropyri-dinepyruvates, which on hydrogenation were transformed into the substituted Et 6-azaindole-2-carboxylates. Cleavage of the ethers and hydrogenation of the resulting pyrrolopyridones yielded the corresponding carboxypyrrole lactams which on decarboxylation and hydrolysis gave the 2-aminomethyl-3-pyrroleacetic acids. Substitution at the C-3 position of the 6-azaindole with a propionic acid and acetic asid side chain and repetition of the above sequence gave porphobilinogen and 2-aminomethyl-3,4-pyrrolediacetic acid.
Journal of the American Chemical Society published new progress about porphobilinogen pyrrole; pyrrole porphobilinogen. 3469-63-4 belongs to class pyridine-derivatives, name is Ethyl 5-methoxy-1H-pyrrolo[2,3-c]pyridine-2-carboxylate, and the molecular formula is C11H12N2O3, Recommanded Product: Ethyl 5-methoxy-1H-pyrrolo[2,3-c]pyridine-2-carboxylate.