Fulopova, Veronika; Gucky, Tomas; Grepl, Martin; Soural, Miroslav published their research in ACS Combinatorial Science on December 10 ,2012. The article was titled 《Solid-Phase Synthesis of Trisubstituted Benzo[1,4]-Diazepin-5-one Derivatives》.Application In Synthesis of 3-Nitroisonicotinic acid The article contains the following contents:
Solid-phase synthesis of 3,4-dihydro-benzo[e][1,4]diazepin-5-ones with three diversity positions is described. Various primary amines were used as the starting material and immobilized on the polystyrene resin equipped with different acid-labile linkers. Polymer-supported amines were converted to α-amino ketones with the use of their sulfonylation with the 4-nitrobenzenesulfonyl chloride (4-Nos-Cl) and subsequent alkylation with α-bromo ketones. After the cleavage of the 4-Nos group, the corresponding α-amino ketones were acylated with various o-nitrobenzoic acids. Reduction of the nitro group followed by spontaneous on-resin ring closure gave the target immobilized benzodiazepines. After acid-mediated cleavage the products were obtained in very good crude purity and satisfactory yields, which makes the developed method applicable for simple library synthesis of the corresponding derivatives in a combinatorial fashion. In the part of experimental materials, we found many familiar compounds, such as 3-Nitroisonicotinic acid(cas: 59290-82-3Application In Synthesis of 3-Nitroisonicotinic acid)
3-Nitroisonicotinic acid(cas: 59290-82-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Application In Synthesis of 3-Nitroisonicotinic acid