Furini, Cristiane R. G. published the artcileMolecular Mechanisms in Hippocampus Involved on Object Recognition Memory Consolidation and Reconsolidation, Application of Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, the main research area is hippocampus memory synaptic protein BDNF; AMPA receptors; BDNF; CaMKII; L-VDCCs calcium channels; ORM consolidation; ORM reconsolidation.
Acquired information is stabilized into long-term memory through a process known as consolidation. Though, after consolidation, when stored information is retrieved they can susceptible, allowing modification, updating, strengthening and re-stabilized a new process referred to as memory reconsolidation. Also, considering that the study of link between synaptic proteins is key to understanding of memory processes, we investigated, in male Wistar rats, mol. mechanisms in the hippocampus involved on ORM consolidation and reconsolidation. We verified that the blockade of AMPAr and L-VDCCs calcium channels impaired ORM consolidation and reconsolidation when administered into CA1 immediately after sample phase or reactivation phase and that these impairments were blocked by the administration of AMPAr agonist and of neurotrophin BDNF. Also, the blockade of CaMKII impaired ORM consolidation when administered 3 h after sample phase but had no effect on ORM reconsolidation and its effect was blocked by the administration of BDNF, but not of AMPAr agonist. So, this study provides new evidence of the mol. mechanisms involved on the consolidation and reconsolidation of ORM, demonstrating that AMPAr and L-VDCCs are necessary for the consolidation and reconsolidation of ORM while CaMKII is necessary only for the consolidation and also that there is a link between BDNF and AMPAr, L-VDCCs and CaMKII as well as a link between AMPAr and L-VDCCs on ORM consolidation and reconsolidation.
Neuroscience (Amsterdam, Netherlands) published new progress about AMPA receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 21829-25-4 belongs to class pyridine-derivatives, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Application of Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.