Furukawa, Naomichi published the artcileSelective ipso-substitution in pyridine ring and its application for the synthesis of macrocycles containing both oxa and thia bridges, Formula: C7H8ClNO, the main research area is macrocycle oxa thio bridge; pyridine sulfinyl sulfonyl ipso substitution; sulfonylpyridine ipso substitution; sulfonylpyridine.
Both the sulfinyl and sulfonyl groups directly bound to 2 or 4 position in pyridine were readily displaced by several nucleophiles such as RO- and RS- (R = alkyl, benzyl). The facility of the leaving groups is RSO2 â?RSO > Br â?Cl â?RS. The ipso-substitution could be applied for the synthesis of new type of 2,6-disubstituted macrocycles I (n = 1, 2, 3) in moderate yields.
Tetrahedron Letters published new progress about macrocycle oxa thio bridge; pyridine sulfinyl sulfonyl ipso substitution; sulfonylpyridine ipso substitution; sulfonylpyridine. 42144-78-5 belongs to class pyridine-derivatives, name is 2-Chloro-6-ethoxypyridine, and the molecular formula is C7H8ClNO, Formula: C7H8ClNO.