Fuse, Hiromu; Nakao, Hiroyasu; Saga, Yutaka; Fukatsu, Arisa; Kondo, Mio; Masaoka, Shigeyuki; Mitsunuma, Harunobu; Kanai, Motomu published the artcile< Photocatalytic redox-neutral hydroxyalkylation of N-heteroaromatics with aldehydes>, Formula: C7H7NO, the main research area is hydroxy alkylated isoquinoline preparation; isoquinoline aldehyde hydroxyalkylation photocatalyst; alkylated hydroxy pyridine preparation; pyridine aldehyde hydroxyalkylation photocatalyst; quinoline hydroxy alkylated preparation; aldehyde quinoline hydroxyalkylation photocatalyst.
Hydroxyalkylation of N-heteroaromatics with aldehydes was achieved using a binary hybrid catalyst system comprising an acridinium photoredox catalyst and a thiophosphoric acid organocatalyst. This metal-free hybrid catalysis proceeded under mild conditions for a wide range of substrates, including quinolines, isoquinolines and pyridines as N-heteroaromatics and both aromatic and aliphatic aldehydes to afford hydroxy-alkylated quinolines I [R = H, 6-F, 7-Br, etc; R1 = Me, Ph, propan-1-ol; R2 = Cl, propan-1-ol], hydroxy-alkylated isoquinolines II [R4 = Et, Ph, 4-FC6H4, etc.] and hydroxy-alkylated pyridines III [R5 = H, Br, Ph; R6 = C(O)Me, CO2Me]. The reaction was applicable to late-stage derivatization of drugs and their leads.
Chemical Science published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Formula: C7H7NO.