In 2022,Gallant, Sarah K.; Tipker, Ryan M.; Glueck, David S. published an article in Organometallics. The title of the article was 《Copper-Catalyzed Asymmetric Alkylation of Secondary Phosphines via Rapid Pyramidal Inversion in P-Stereogenic Cu-Phosphido Intermediates》.Quality Control of 2-(Bromomethyl)pyridine hydrobromide The author mentioned the following in the article:
Development of metal-catalyzed asym. synthesis of P-stereogenic phosphines was guided by the hypothesis that pyramidal inversion occurs rapidly in metal-phosphido intermediates, but this process was not observed directly for all metals of interest. The authors report an enantioselective Cu(Josiphos)-catalyzed alkylation of secondary phosphines and observation of the reaction intermediates, including variable temperature NMR studies of low-barrier pyramidal inversion at P in the key P-stereogenic terminal phosphido complexes Cu(diphos*)(PRR’), and a study of their reversible formation from secondary phosphine-silanolate complexes Cu(diphos*)[PHR(R’)](OSiMe3). The experimental process involved the reaction of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Quality Control of 2-(Bromomethyl)pyridine hydrobromide)
2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Quality Control of 2-(Bromomethyl)pyridine hydrobromide