Gan, Xinmin; Showalter, Hollis D. published the artcile< A concise synthesis of 3-substituted-7-amino-6-carboxyl-8-azachromones>, Application of C11H16BNO2, the main research area is azachromone amino carboxyl preparation; 4H-pyrano[2,3-b]pyridin-4-one; 8-azachromone; obesity; palladium catalyzed cross-couplings.
We report on an approach to truncate the tricyclic 5H-chromeno[2,3-b]pyridin-5-one core of amlexanox, an approved drug under investigation for the treatment of obesity, to the bicyclic 4H-pyrano[2,3-b]pyridin-4-one (8-azachromone) core. A short, concise synthesis generates a key intermediate with requisite functionality on the pyridyl A-ring and iodo functionality on the 4-pyrone B-ring upon which palladium-catalyzed cross-coupling and subsequent reactions generate representative analogs. One of these shows a 14.2-fold increase in aqueous solubility over amlexanox.
Tetrahedron Letters published new progress about Chromones Role: SPN (Synthetic Preparation), PREP (Preparation) (aza). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Application of C11H16BNO2.