Synthesis and herbicidal activity of 2-cyano-3-methylthio-3-(substituted methylamino)acrylates was written by Gao, Ying;Zou, Xiao-Mao;Yu, Li-Min;Xu, Han;Liu, Bin;Zhu, You-Quan;Hu, Fang-Zhong;Yang, Hua-Zheng. And the article was included in Chinese Journal of Chemistry in 2006.Recommanded Product: 6-Fluoronicotinonitrile This article mentions the following:
A series of 3-amino-2-cyano-3-(methylthio)acrylates were synthesized as herbicidal inhibitors of photosystem II electron transport, in order to estimate the effect of fluorine atom, pyridyl group, chirality, and ester chain on activity. The important intermediate 2-fluoro-5-(aminomethyl)pyridine was synthesized with high yield. The bioassay results showed that most of title compounds had high herbicidal activity in postemergence treatment. The introduction of an α-Me into the 3-substituted methylamino could improve the activity notably. The replacement of H by Cl or F group and Ph by pyridyl group showed different effects, and at the same time, the ester chain affected the activity too. In the experiment, the researchers used many compounds, for example, 6-Fluoronicotinonitrile (cas: 3939-12-6Recommanded Product: 6-Fluoronicotinonitrile).
6-Fluoronicotinonitrile (cas: 3939-12-6) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: 6-Fluoronicotinonitrile