Gargaro, Samantha L.; Klake, Raphael K.; Burns, Kevin L.; Elele, Sharon O.; Gentry, Skyler L.; Sieber, Joshua D. published the artcile< Access to a Catalytically Generated Umpolung Reagent through the Use of Cu-Catalyzed Reductive Coupling of Ketones and Allenes for the Synthesis of Chiral Vicinal Aminoalcohol Synthons>, Recommanded Product: 1-(Pyridin-3-yl)ethanone, the main research area is oxazolidinone homoallylic alc asym synthesis; ketone regioselective stereoselective reductive coupling oxazolidinyl allene copper catalyst.
Herein, a stereoselective method for the allylation of ketones R1C(O)R2 [R1 = Ph, 4-MeOC6H4, 2-naphthyl, 3-pyridyl, N-tosylpyrrol-3-yl, etc., R2 = Me; R1 = Ph, R2 = Et; R1R2 = 2-C6H4(CH2)3] with a chiral allenamide I is reported. By employing N-heterocyclic carbenes as ligands for the Cu catalyst, good branched selectivity can be obtained with high diastereocontrol. This methodol. allows access to a catalytically generated, polarity-reversed (umpolung) allyl nucleophile to enable the preparation of chiral 1,2-aminoalc. synthons II containing a dissonant functional group relationship.
Organic Letters published new progress about Allenes Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Recommanded Product: 1-(Pyridin-3-yl)ethanone.