Gaut, Z. N.; Solomon, H. M. published an article in 1971, the title of the article was Inhibition of nicotinate phosphoribosyltransferase in human platelet lysate by nicotinic acid analogs.Application In Synthesis of Pyridine-3-sulfonic acid And the article contains the following content:
Nicotinate phosphoribosyltransferase in human platelet lysate has an apparent Km of 24 μM, is Mg2+-dependent, and catalyzes the first step in NAD biosynthesis (substrate: nicotinic acid). The pyridine N and carboxyl groups are important for interaction with the enzyme; large substituents (Br, NH2, CH2OH) in the 2-position of nicotinic acid apparently create steric hindrance of the pyridine N and produce low inhibitory activity for these compounds toward the enzyme. Positions 4 and 5 are also involved sterically since compounds such as 4-hydroxynicotinic acid are not inhibitory (at 0.5mM). The data indicate a size-restricted, hydrophobic region at the enzyme active site to accommodate atoms 4, 5, and possibly 6 of the pyridine ring. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Application In Synthesis of Pyridine-3-sulfonic acid
The Article related to nicotine phosphoribosyltransferase inhibition, active site nicotine phosphoribosyltransferase, transferase nicotine phosphoribosyl inhibition, blood platelet, michaelis constant, reaction kinetics, structure-activity relationship and other aspects.Application In Synthesis of Pyridine-3-sulfonic acid