Ge, Xin published the artcileA concise synthesis of 2-chloro-3-amino-4-methylpyridine, Application In Synthesis of 133627-45-9, the main research area is pyridinamine chloro methyl preparation.
An improved and com. valuable process is developed for the scalable synthesis of 2-chloro-3-amino-4-methylpyridine [CAPIC, a key intermediate of Nevirapine]. The synthesis was accomplished in four steps, featuring a condensation reaction starting from 4,4-dimethoxy-2-butanone and cyanoacetamide with ammonium acetate and acetic acid as catalyst. The total yield of the process is 62.1%. The pure CAPIC sample was confirmed with FTIR, 1H-NMR and 13C-NMR.
Research on Chemical Intermediates published new progress about Chlorination. 133627-45-9 belongs to class pyridine-derivatives, name is 2-Chloro-4-methylpyridin-3-amine, and the molecular formula is C6H7ClN2, Application In Synthesis of 133627-45-9.