Gelboin, Harry V. published an article in 1966, the title of the article was Drugs and protein synthesis.Application of 636-73-7 And the article contains the following content:
Methylcholanthrene (I) and phenobarbital (II) are both capable of inducing specific messenger RNA and enzyme synthesis. Treatment of rats with I elevates tissue hydroxylase activity 7-30-fold at 14 hrs. The increase is lowered or prevented by protein synthesis inhibitors actinomycin D and puromycin. During a 20-min. pulse labeling, the liver microsomes of rats treated with I or II showed a greater amino acid incorporation than control microsomes. This increased amino acid incorporation is not the result of altered cofactor levels, activation of pre-existing enzymes, altered stability of messenger RNA, or to drug-induced changes in the endogenous pool of amino acids. L-Phenylalanine-U-14C incorporation in the microsomes from rats treated with I contain an increased level of polyuridylic acid and are more sensitive to added polyuridylic acid than control microsomes. Pretreatment of rat liver nuclei with I results in an increased level of orotic-14C incorporation into RNA and in an elevated RNA/DNA ratio. The RNA present in nuclei of rats treated with I had greater messenger RNA activity in the Nirenberg Escherichia coli protein synthesizing system than did RNA from similarly isolated control nuclei. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Application of 636-73-7
Pyridine-3-sulfonic acid(cas:636-73-7) belongs to pyridine-derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Application of 636-73-7