Recommanded Product: 39901-94-5. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Picolinoyl chloride hydrochloride, is researched, Molecular C6H5Cl2NO, CAS is 39901-94-5, about Discovery, Synthesis, and Structure-Activity Relationship Development of a Series of N-(4-Acetamido)phenylpicolinamides as Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4 (mGlu4) with CNS Exposure in Rats. Author is Engers, Darren W.; Field, Julie R.; Le, Uyen; Zhou, Ya; Bolinger, Julie D.; Zamorano, Rocio; Blobaum, Anna L.; Jones, Carrie K.; Jadhav, Satyawan; Weaver, C. David; Conn, P. Jeffrey; Lindsley, Craig W.; Niswender, Colleen M.; Hopkins, Corey R..
The discovery, synthesis, and evaluation of a series of N-(4-acetamido)-phenylpicolinamides, e.g., I as pos. allosteric modulators of mGlu4. Compounds from the series show submicromolar potency at both human and rat mGlu4. In addition, pharmacokinetic studies utilizing s.c. dosing demonstrated good brain exposure in rats.
There is still a lot of research devoted to this compound(SMILES：O=C(Cl)C1=NC=CC=C1.[H]Cl)Recommanded Product: 39901-94-5, and with the development of science, more effects of this compound(39901-94-5) can be discovered.