Recently I am researching about CARBON BOND FORMATION; ONE-POT SYNTHESIS; SILOXY SERINE ORGANOCATALYST; DYNAMIC KINETIC RESOLUTION; DIELS-ALDER REACTION; BETA-AMINO; BIOCATALYTIC PROMISCUITY; ENANTIOSELECTIVE SYNTHESIS; ENZYME PROMISCUITY; ALPHA-CHYMOTRYPSIN, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21672174]; Basic and Frontier Research Project of Chongqing [cstc2015jcyjBX0106]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Chen, YJ; Xiang, Y; He, YH; Guan, Z. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde. Category: pyridine-derivatives
The anti-selective direct asymmetric Mannich reaction of (hetero) aromatic aldehydes, 4-anisidine and O-protected hydroxyacetones for the synthesis of stereodefined anti-beta-amino-alpha-hydroxycarbonyl compounds was developed. Protease type XIV from Streptomyces griseus (SGP) was used as a biocatalyst in 1,4-dioxane/phosphate buffer under mild reaction conditions. The excellent diastereoselectivities of up to >99:1 (anti/syn) and good enantioselectivities of up to 90% ee were achieved. This method provides a more sustainable complement to chemically catalyzed anti-selective direct asymmetric Mannich reactions. (C) 2019 Elsevier Ltd. All rights reserved.
About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Chen, YJ; Xiang, Y; He, YH; Guan, Z or concate me.. Category: pyridine-derivatives
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem