Ghiazza, Clement; Faber, Teresa; Gomez-Palomino, Alejandro; Cornella, Josep published an article on January 31 ,2022. The article was titled 《Deaminative chlorination of aminoheterocycles》, and you may find the article in Nature Chemistry.Application In Synthesis of 4-Amino-2-picoline The information in the text is summarized as follows:
Herein we present a simple methodol. that enabled the NH2 groups in aminoheterocycles to be conceived as masked modification handles. With the aid of a simple pyrylium reagent and a cheap chloride source, C(sp2)-NH2 could be converted into C(sp2)-Cl bonds. The method was characterized by its wide functional group tolerance and substrate scope, allowing the modification of different classes of heteroaromatic motifs (five- and six-membered heterocycles), bearing numerous sensitive motifs. The facile conversion of NH2 into Cl in a late-stage fashion enabled practitioners to apply Sandmeyer- and Vilsmeier-type transforms without the burden of explosive and unsafe diazonium salts, stoichiometric transition metals or highly oxidizing and unselective chlorinating agents. After reading the article, we found that the author used 4-Amino-2-picoline(cas: 18437-58-6Application In Synthesis of 4-Amino-2-picoline)
4-Amino-2-picoline(cas: 18437-58-6) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Application In Synthesis of 4-Amino-2-picoline