The application of perfluoroheteroaromatic reagents in the preparation of modified peptide systems was written by Gimenez, Diana;Mooney, Caitlin A.;Dose, Anica;Sandford, Graham;Coxon, Christopher R.;Cobb, Steven L.. And the article was included in Organic & Biomolecular Chemistry in 2017.Formula: C5F5N The following contents are mentioned in the article:
The perfluoroheteroarom. reagent pentafluoropyridine has proved to be a highly reactive electrophile, undergoing SNAr arylation reactions in the presence of a range of nucleophilic peptide side chains (i.e. cysteine, tyrosine, serine and lysine) under mild conditions. Moreover, we have shown how one-step peptide-modification using perfluoroheteroaroms. can deliver enhanced proteolytic stability in pharmaceutically-relevant peptides such as oxytocin and vasopressin. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Formula: C5F5N).
2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine derivatives are also useful as small-molecule ä¼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Formula: C5F5N