On June 28, 2007, Glatthar, Ralf; Orain, David; Spanka, Carsten published a patent.SDS of cas: 85614-89-7 The title of the patent was Preparation of nicotinic acid derivatives as modulators of mGluR5 metabotropic glutamate receptors. And the patent contained the following:
Title compounds [I; R1 = (substituted) alkyl, PhCH2; R2 = H, (substituted) alkyl, PhCH2; R1R2N = (substituted) heterocyclyl; R3, R4 = halo, OH, alkyl, alkoxy, amino, alkylamino, dialkylamino; Q, V, W = CH, CR4, N; X = CH, N; Y = CH, CR3, N; Z = CR6aR6b, NR5, O; R5 = H, OH; R6a, R6b = H, halo, OH, amino, alkyl, alkoxy, haloalkyl; provided that Q, V, W are not all N], were prepared Thus, 6-chloro-N,N-diethylnicotinamide (preparation given) and 4-chloroaniline were heated in aqueous HOAc in a sealed vial at 100° overnight to give after chromatog. 6-(4-chlorophenylamino)-N,N-diethylnicotinamide hydrochloride. The latter at 10 μM gave 95% inhibition of mGluR5 activity. The experimental process involved the reaction of Ethyl 5-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate(cas: 85614-89-7).SDS of cas: 85614-89-7
The Article related to nicotinic acid derivative preparation mglur5 metabotropic glutamate receptor modulator, gastrointestinal nervous system urinary tract disorder treatment, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.SDS of cas: 85614-89-7