On March 20, 2008, Glatthar, Ralf; Johns, Donald; Umbricht, Daniel published a patent.Application of 85614-89-7 The title of the patent was Preparation of pyridine derivatives as modulators of metabotropic glutamate receptors. And the patent contained the following:
Title compounds represented by the formula I [wherein R1 – (un)substituted alkyl or benzyl; R2 = H, alkyl or (un)substituted benzyl; or R1R2N = (un)substituted heterocyclyl; R3 = halo, alkoxy, alkyl(amino) or dialkylamino; R4 = OH, halogen, alkyl or alkoxy; Q = CH, CR4 or N; V = CH, CR4 or N; W = CH, CR4 or N; X = CH or N; Y = CH, CR3 or N; Z = CH2, NH or O; provided that Q, V and W are not N at the same time; and in free base or acid addition salt form] were prepared as metabotropic glutamate receptors (mGluR) antagonist, especially mGluR5 antagonist,. For example, reaction of 6-chloro-N,N-diethylnicotinamide with 4-chloroaniline gave II in 56% yield. I were tested for inhibition of the glutamate induced elevation of intracellular Ca2+-concentration at a concentration of 10 μM, and I were also in clin. testing. Thus, I and their pharmaceutical compositions are useful as mGluR modulator for the treatment, prevention or delay of progression of cognitive dysfunction. The experimental process involved the reaction of Ethyl 5-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate(cas: 85614-89-7).Application of 85614-89-7
The Article related to pyridine derivative preparation metabotropic glutamate receptor modulator, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application of 85614-89-7