Gonzalez-Montelongo, Maria del Carmen published the artcileNeuropeptide Y facilitates P2X1 receptor-dependent vasoconstriction via Y1 receptor activation in small mesenteric arteries during sympathetic neurogenic responses, Safety of Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, the main research area is Neuropeptide Y P2X1 Suramin vasoconstriction NF449 Calcium channel; Calcium channel; Neurogenic; Neuropeptide Y; P2X receptors; Vasoconstriction.
Investigate effect of NPY on P2X1-dependent vasoconstriction in mesenteric arteries. Suramin or P2X1 antagonist NF449 abolished α,β-meATP evoked vasoconstrictions. Y1 receptor inhibition (BIBO3304) reversed NPY facilitation of α,β-meATP-evoked vasoconstriction. L-type Ca2+ channel antagonism (nifedipine) had no effect on α,β-meATP-evoked vasoconstrictions, but completely reversed NPY. Elec. field stimulation evoked sympathetic neurogenic vasoconstriction. Neurogenic responses dependent upon dual α1-adrenergic (prazosin) and P2X1 (NF449) receptor activation. Y1 receptor antagonism reduced neurogenic vasoconstriction. Isolation of P2X1 component by α1-adrenergic blockade faciliatory effects of Y1 receptor activation explored. Y1 receptor antagonism reduced P2X1 receptor component during neurogenic vasoconstriction. α1-adrenergic and P2X1 receptors post-junctional receptors during sympathetic neurogenic vasoconstriction in mesenteric arteries. Identified that NPY lacks direct vasoconstrictor effect in mesenteric arteries but can vasoconstriction by enhancing activity of P2X1, activation by exogenous agonists or during sympathetic nerve stimulation. Mechanism of P2X1 facilitation by NPY involved activation of NPY Y1 receptor and L-type Ca2+ channel.
Vascular Pharmacology published new progress about Adrenoceptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 21829-25-4 belongs to class pyridine-derivatives, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Safety of Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.