Chemoselective, osmium-free, dihydroxylation/oxidative cleavage of heteroaryl isoprenes by a contemporary Malaprade reaction was written by Gulledge, Zachary Z.;Pinson, Connor C.;Stovall, Alexander M.;Dzeagu, Fortune O.;Carrick, Jesse D.. And the article was included in Organic & Biomolecular Chemistry in 2022.Product Details of 91-02-1 This article mentions the following:
In this work authors present the development and application of an oxidative cleavage reaction of various pyridinyl isoprenes towards accessing the downstream Me ketone for utilization in advanced cyclizations for the preparation of soft-N-donor complexant scaffolds. This efficient protocol parallels the principles of Green chem. by exchanging KMnO4 for the toxic OsO4 and offers the end-user an efficient, more environmentally friendly option for accessing heteroaryl Me ketones in one hour of reaction time using potassium permanganate and sodium paraperiodate as a synergistically potent oxidative cleavage system. The wide substrate scope defined access to simple, as well as advanced heteroaryl Me ketones. Method development, optimization, substrate scope, preliminary mechanistic observations, and a scale up reaction are delineated herein. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Product Details of 91-02-1).
Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Product Details of 91-02-1