The author of 《Palladium-catalyzed carbonylative synthesis of indoloisoindoloquinazolinone derivatives by using CO as a carbonyl source》 were Guo, Shenghai; Wang, Fang; Liu, Yangfan; Fan, Xuesen. And the article was published in Tetrahedron in 2019. Application In Synthesis of 2-Bromonicotinaldehyde The author mentioned the following in the article:
An efficient synthesis of indolo[1,2-c]isoindolo[2,1-a]quinazolin-5(16aH)-one derivatives through palladium-catalyzed cyclocarbonylation reaction of 6-(2-bromoaryl)-5,6-dihydroindolo[1,2-c]quinazolines with the use of CO as a carbonyl source under atm. pressure has been disclosed. More intriguingly, the above-mentioned products can also be obtained directly from a one-pot two-step tandem reaction of 2-(1H-indol-2-yl)anilines and 2-bromobenzaldehydes, which are the precursors of 6-(2-bromoaryl)-5,6-dihydroindolo[1,2-c]quinazolines, under an atm. CO pressure in modest yields. In the part of experimental materials, we found many familiar compounds, such as 2-Bromonicotinaldehyde(cas: 128071-75-0Application In Synthesis of 2-Bromonicotinaldehyde)
2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Application In Synthesis of 2-Bromonicotinaldehyde